The Value-added Fractionation and Natural and Non-prescription Health Products (NNHP) Program helps to accelerate product development, optimization and commercialization by providing business development tools and technical services to emerging and established companies. A dedicated formulation lab enables clients to develop novel cosmetic, personal care and topical NNHPs while the BPIC facility is equipped with specialized equipment for extraction and purification on a pilot scale.
Our team can also provide training on specialized equipment and help companies navigate regulatory hurdles in the NNHP sector. We have a robust Quality Management system ensuring Good Manufacturing Practices are adhered to.
Table 1. Equipment – Value-added Fractionation and NNHP Program
Process | Capacity |
High temperature/pressure reactions | Contact for details |
Particle size and size distribution analysis | Beckman Coulter LS 13320 (from Nano size up to 2000 nm) |
Pressurized extraction | 0.5 to 2 litres (lab scale); Timatic Micro extractor (up to 8 bar) |
Essential oil extraction | 2 litres (lab scale) to 30 litres (BPIC) |
Thermo-combustion protein analysis | LECO FP-628 nitrogen/protein analyzer |
Low/medium pressure chromatography | Contact for details |
Ultra-high-performance liquid chromatography | Dionex UltiMate 3000 U/HPLC with IR, UV and ELSD detectors |
Membrane filtration | Tubular and spiral membranes (MF, UF, NF and RO); Membrane Specialists Lab unit (4-80L batch sizes) |
Near-infrared spectroscopy | Contact for details |
Fourier-transform infrared spectroscopy | Contact for details |
Cosmetic and NNHP formulation | Fully-stocked laboratory for formulation development |
Cold oilseed press | Montforts CA59-G3 |
Gas Chromatograph | Agilent 6890 GC Series |
Pilot scale wet processing
Since 2017, BPIC has operated with a Health Canada NNHP site licence and a 4,800 ft2 wet processing area that accommodates extraction and purification of a wide range of biomass including oilseeds, cereal grains, specialty crops, botanicals and biomass secondary process streams. Process equipment is available for purifying and concentrating crude botanical extracts, including a pilot scale spray dryer which can remove water at 20 to 60 litres per hour.
Table 2. Equipment – Pilot scale wet processing
Process | Capacity |
Milling | Contact for details |
Sieving | Contact for details |
Seed oil expelling | 200-300 kg seed processed/hr |
Filter press | 24" plate and frame; 1,000 L/hr depending on filter porosity; Hillard Star, cold and hot filtering |
Pressurized extraction | 100 and 200L vessels, Timatic 100/200 |
Membrane filtration | Tubular and spiral membranes up to 1,000L/hr depending on the membranes used (NF, UF, NF and RO); Membrane Specialists – Custom design |
Fractional distillation | 22L Batch Fractionation with max. temperature up to 250°C and vacuum up to 30 mmHg |
Freeze drying | SP Ultra pilot and small production lyophilizer with max. condenser capacity 35 L |
Tray drying | Mechanical convection oven with the capacity of 24 Cu. ft and max. temp of 350°C |
Spray drying | 20 to 60 kg per hour |
Scale-up manufacturing suite
Table 3. Equipment – Scale-up manufacturing suite
Process | Capacity |
Batch processing | 20 to 2,000 litres |
Wax melting and hot filling | 400 litres; WaxMelters 300 |
Packaging | Bottles and jars from 15 mL to 4,000 mL; tubes from 60 to 250 mL |
Sample filler | Up to 50 mL |
Automatic filling machine | Filamatic EconoFIL (bottles and jars from 50ml-2L) |
Piston filler | 50 to 4,000 mL; Technopack, both hopper and vat units; multiple piston heads for a wide range of bottles, jars and tubes. |
Product coder | Anser U2 Pro Thermal Inkjet Printer |
Tubing Sealer | Sorbent Systems MSTSS760/TP-30 |
Tamperproof Seal Heat shrink tunnel | Jorestech TUN-1540 |
Bag/Pouch sealer | Technopack |
Induction sealer | Technopack |
Small volume filler | Jorestech magnetic filler |
Automated labeler and coder | Busch Machinery |
Semi-automated labeler | Jorestech Omicron-50 |
Semi-automated cardboard box/case closer | Technopack |